Isabella d’Este (1474-1539), Marchioness of Mantua, Italy, had an artistic relationship with Leonardo da Vinci. Beginning in late 1499, Leonardo spent several months with her at the Ducal Palace in Mantua and produced a finished portrait drawing of her. In the years that followed, Isabella wrote to the artist to ask him to undertake other paintings and projects. Isabella’s son Federico II Gonzaga (1500-1540), Duke of Mantua, met Leonardo while in Amboise. Isabella d’Este had an artistic relationship with Titian who painted portraits of her in 1529 and 1534-1536 and her son Federico II Gonzaga also had an artistic relationship with Titian who painted portraits of him in 1529 and 1530. In 1536-40 Titian painted for the Duke the original series of eleven half- length portraits of Roman emperors. Historical sources state there were twelve Roman emperor paintings, the twelfth being Domitian (version 1), on display at the Ducal Palace in Mantua in the 16th century.